Am I Eligible?

• Physical examinations
• Memory and thinking tests
• Positron Emission Tomography (PET) scans (pictures of your brain taken by a device similar to an x-ray, after injecting a small dose of a detectable dye in your arm to look for the amyloid plaques and tau tangles associated with Alzheimer’s disease).
• Magnetic Resonance Imaging (MRI) scans (pictures of your brain taken by a device similar to an x-ray to assess changes in your brain structure)
• Blood and urine tests
• Once or twice-a-month intravenous (IV) infusions of an investigational treatment (or placebo) that aims to help remove amyloid plaques from the brain

Clinical trials carefully assess whether each interested person is eligible to participate. This is done for two main reasons: 1) to protect the health and safety of people who wish to enroll, and 2) to protect the scientific integrity of the study.

Like most clinical trials, the AHEAD Study has specific inclusion criteria - such as being a certain age or having a study partner – and exclusion criteria – such as not having certain medical conditions.

Please answer the following questions to find out if you might be eligible to screen for the AHEAD Study. This should only take a few minutes to complete. At the end, you will be told if you may be eligible and will be given contact information for a research center near you, which you may contact directly, or have your contact information shared with a local research center and have someone there contact you. If you’d prefer to speak to a representative about your eligibility for the study, please call 1-800-AHEAD-70 (1-800-243-2370).

Thank you for taking the time to answer these questions. Unfortunately, the answers you provided indicate that you are not likely to be eligible to participate in the AHEAD Study at this time, as explained below.

• The AHEAD Study is only enrolling adults ages 55-80 years old. Those 55-64 years old must have an additional risk factor to be screened for the AHEAD Study.

• The AHEAD Study is a trial for people who have normal thinking and memory function and do not have dementia.

• Participants must not have a pacemaker or other metal device that would prevent them from having an MRI.

However, there may be opportunities for you to participate in future studies.