Am I Eligible?

Answer a few questions to see if you may be eligible for the AHEAD Study. Take the online survey or if you’d prefer to speak to a representative about your eligibility for the study, please call 1-800-AHEAD-70 (1-800-243-2370).

Participants eligible for the AHEAD Study:
- Are healthy adults ages 55-80
- Have not been diagnosed with Alzheimer’s disease
The AHEAD Study is a four-year clinical trial evaluating a potential treatment to slow the earliest brain changes and may help prevent symptoms associated with Alzheimer’s disease. The study requires a number of medical procedures that will be performed at no cost to participants, including:
- Physical examinations
- Memory and thinking tests
- Positron Emission Tomography (PET) scans (pictures of your brain taken by a device similar to an x-ray, after injecting a small dose of a detectable dye in your arm to look for the amyloid plaques and tau tangles associated with Alzheimer’s disease).
- Magnetic Resonance Imaging (MRI) scans (pictures of your brain taken by a device similar to an x-ray to assess changes in your brain structure)
- Blood and urine tests
- Once or twice-a-month intravenous (IV) infusions of an investigational treatment (or placebo) that aims to help remove amyloid plaques from the brain
Are you potentially interested in participating in the AHEAD Study?*
- Yes
- No

There may be opportunities for you to participate in future studies. If you are interested in being contacted for these opportunities, please indicate this below and we will follow up with a couple more questions on the best way to contact you.*
- Yes
- No

Clinical trials carefully assess whether each interested person is eligible to participate. This is done for two main reasons: 1) to protect the health and safety of people who wish to enroll, and 2) to protect the scientific integrity of the study.

Like most clinical trials, the AHEAD Study has specific inclusion criteria - such as being a certain age or having a study partner – and exclusion criteria – such as not having certain medical conditions.

Please answer the following questions to find out if you might be eligible to screen for the AHEAD Study. This should only take a few minutes to complete. At the end, you will be told if you may be eligible and will be given contact information for a research center near you, which you may contact directly, or have your contact information shared with a local research center and have someone there contact you. If you’d prefer to speak to a representative about your eligibility for the study, please call 1-800-AHEAD-70 (1-800-243-2370).
Question 1*
Are you between the ages of 55 and 80 years old?
- Yes
- No
Question 1A*
Are you between the ages of 55 and 64 years old?
- Yes
- No
If you are between the ages of 55-64, you must have an additional risk factor to be screened for the AHEAD Study:
Question 1B*
Do you have a first-degree family member (parent, sibling) who had symptoms of Alzheimer’s disease before age 75?
- Yes
- No
- Do not know
Question 1C*
Have you been tested for genes associated with Alzheimer’s disease? If so, do you carry a copy of the gene (apolipoprotein E, APOE4)? You may know if you possess the APOE4 gene if you have previously completed genetic testing.
- Yes
- No
- Do not know
Question 1D*
Have you been tested for biomarkers for Alzheimer’s disease (amyloid PET imaging, cerebrospinal fluid, or blood test)? If so, do you have evidence of abnormal levels of amyloid on one of these tests?
- Yes
- No
- Do not know
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+1 for each age-related factor.

Question 2*
The AHEAD Study is a trial for people who have normal thinking and memory function and do not have dementia. Have you been diagnosed with Alzheimer’s disease dementia or another type of dementia, mild cognitive impairment (MCI), or any other cognitive or neurological disorder?
- Yes
- No
Question 3*
Do you have a pacemaker, defibrillator, or metal implants that would prohibit you from having an MRI? Please note: if the metal object is an artificial knee or hip replacement, please answer “no” as these joint replacements are safe to go into MRI.
- Yes
- No
These next few questions are not required for eligibility for the study – but may help researchers find people who are the best fit for this study.
Question 4*
Do you have a living or deceased parent or sibling who was diagnosed with Alzheimer's disease or dementia?
- Yes
- No
- Do not know
- Prefer not to answer
Question 5*
Compared to 1 year ago, do you feel that your memory has declined, even though you are still functioning independently?
- Yes
- No
- Maybe
- Prefer not to answer
Question 6*
A key goal of our trials is to better represent the demographics of our diverse nation. Would you mind indicating all of the following that represent your race and ethnicity?
- American Indian or Alaska Native
- Asian
- Black/African American
- Caucasian
- Hispanic/Latino
- Native Hawaiian or Pacific Islander
- Prefer not to answer

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Thank you for taking the time to answer these questions. Unfortunately, the answers you provided indicate that you are not likely to be eligible to participate in the AHEAD Study at this time, as explained below.
- The AHEAD Study is only enrolling adults ages 55-80 years old. Those 55-64 years old must have an additional risk factor to be screened for the AHEAD Study.
- Those 55-64 years old must have an additional risk factor to be screened for the AHEAD Study.
- The AHEAD Study is a trial for people who have normal thinking and memory function and do not have dementia.
- Participants must not have a pacemaker or other metal device that would prevent them from having an MRI.
However, there may be opportunities for you to participate in future studies.
If you are interested in being contacted for these opportunities, please indicate below and we will follow up with a couple more questions on the best way to contact you.*
- Yes! Please collect my contact information and alert me of future opportunities.
- No thank you, not at this time.
Thank you! You may be eligible to screen for the AHEAD Study. What would you like to do next?*
- I would like to have my information automatically shared with the research center nearest me and have them contact me about next steps.
- I would prefer to directly contact a research center near me about next steps.

Great! Please provide us with the following information so that we can contact you:
Great! In order for us to send your information to a local research center, please provide us with the following information so that we can find the one nearest to you.
Thank you, we will not automatically send your information to a research center. Since you stated that you would like to personally reach out to a research center about next steps, please provide the zip code/postal code of your primary residence, so that we can help find an AHEAD Study research location near you. You can also use the interactive map on the Locations tab of the website to find research locations near you. Please note that additional AHEAD Study research loctions will be coming on board soon – so please feel free to check back in a few weeks.
Name*
First Last
The best phone number to reach you*
If you wish to provide a second phone number, please do so here
Email*
The zip code or postal code of your primary residence*
Zip/Postal Code
A key goal of our trials is to better represent the demographics of our diverse nation. Would you mind indicating all of the following that represent your race and ethnicity?*
A key goal of our trials is to better represent the demographics of our diverse nation. Would you mind indicating all of the following that represent your race and ethnicity?
- American Indian or Alaska Native
- Asian
- Black/African American
- Caucasian
- Hispanic/Latino
- Native Hawaiian or Pacific Islander
- Prefer not to answer

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*
- Yes!
- No thank you, not at this time.

Great! Please provide us with the following information so that we can contact you:
Name*
First Last
The best phone number to reach you*
If you wish to provide a second phone number, please do so here
Email*
The zip code or postal code of your primary residence*
Zip/Postal Code

AHEAD Study Organizers

The AHEAD Study is funded by the National Institutes of Health and several philanthropic organizations, as well as Eisai, the company that makes the investigational treatment used in the study. It is being conducted by the NIH-funded Alzheimer’s Clinical Trials Consortium (ACTC), a network of leading academic Alzheimer’s research centers. The study is coordinated by the University of Southern California’s Alzheimer’s Therapeutic Research Institute, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School. Cooperative agreement number: R01AG054029 (A3), R01AG061848 (A45)

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Am I Eligible?

Answer a few questions to see if you may be eligible for the AHEAD Study. Take the online survey or if you’d prefer to speak to a representative about your eligibility for the study, please call 1-800-AHEAD-70 (1-800-243-2370).

AHEAD Study Organizers

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